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Table 4. Decision table based on the key simulation findings under the considered scenarios

From: Forced randomization: the what, why, and how

  1. “Non-zero” balance for FR1a refers to the possibility of observing a quite significant treatment imbalance depending on the number of skipped randomization numbers on the list that are not backfilled (thereby closing the gap towards complete balance). “Almost perfect” balance for FR1b can be observed despite back-filling depending on the resupply levels at other sites. However, due to the backfilling option this will be markedly lower than the FR1a option
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BMC Medical Research Methodology

ISSN: 1471-2288

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