Table 1 Probability conversion table for MODY using the Original method with an adjusted pre-test probability. (A) Model using clinical features only adjusting to population prevalence of MODY (0.6%), (B) model using clinical features but adjusting to population prevalence of MODY based on patients who are C-peptide positive and antibody negative (7.3%). Parentheses are used to signify that an endpoint value is not included. Bracket are used to signify that an endpoint value is included
(A) Original model adjusting probabilities for prevalence [scenario a)] (pre-test probability = 0.6%) | (B) Original model adjusting probabilities assuming patients have biomarker tests suggesting increased risk of MODY [scenario b)] (pre-test probability=7.3%) | ||
|---|---|---|---|
Case-control model probability (%) | Post-recalibration probability (%) | Case-control model probability (%) | Post-recalibration probability (%) |
(0, 10) | 0.6 | (0, 10) | 7.3 |
[10, 20) | 1.6 | [10, 20) | 17.9 |
[20, 30) | 2.3 | [20, 30) | 23.2 |
[30, 40) | 3.4 | [30, 40) | 31.6 |
[40, 50) | 4.2 | [40, 50) | 36.6 |
[50, 60) | 5.5 | [50, 60) | 43.1 |
[60, 70) | 6.2 | [60, 70) | 46.5 |
[70, 80) | 7.1 | [70, 80) | 49.9 |
[80, 90) | 10.9 | [80, 90) | 61.6 |
[90, 100] | 45.4 | [90, 100] | 91.6 |